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What is Preimplantation Genetic Diagnosis (PGD)

In our journey to parenthood, we encounter the beautiful complexity of our genetic makeup. Each of us carries a unique set of genes, which can present both advantages and challenges. Preimplantation genetic diagnosis (PGD) steps in as a valuable tool, particularly for couples undergoing in vitro fertilization (IVF), offering insight into any genetic issues within embryos before pregnancy begins. It’s a way to ascertain whether genetic abnormalities present in the parents might also be carried by an embryo. Couples opting for PGD often aren’t facing infertility but may have a family history of significant health issues or wish to reduce the risk of genetic conditions affecting their future children.

PGD also serves as an alternative to certain post-pregnancy diagnostic methods such as amniocentesis or chorionic villus sampling. At Dream IVF Cyprus, we specialize in providing dependable services, particularly in IVF and diagnostic procedures like PGD.

What can PGD diagnose?

While Preimplantation genetic diagnosis (PGD) is a powerful tool, it’s important to note that not all genetic conditions can be detected this way. Typically, PGD is employed for single gene disorders and structural changes in parental chromosomes. Some common single gene disorders for which PGD is utilized include:

  • Cystic Fibrosis
  • Sickle Cell Anemia
  • Hemophilia
  • Tay-Sachs Disease
  • Thalassemia
  • Spinal Muscular Atrophy (SMA)

Why is PGD significant?

The journey to conception can be fraught with challenges, and one major hurdle is the potential for abnormal genetic structures in embryos, which may lead to failed IVF attempts or miscarriage. PGD offers crucial insights into whether embryos slated for transfer possess the correct number and functionality of chromosomes. Ultimately, this reduces the likelihood of IVF failure and miscarriage, providing couples with greater assurance as they pursue parenthood.

How does PGD work?

In PGD, embryos are obtained through the IVF method. Multiple eggs are matured, retrieved, and fertilized in a laboratory setting. Once embryos reach the blastocyst stage, a few cells outside the embryo are biopsied and sent for genetic examination. Two primary methods are used for PGD:

  • Polymerase Chain Reaction (PCR): This method amplifies copies of the gene under study, enabling the identification of minute amounts of DNA for diagnosis.
  • Fluorescent in Situ Hybridization (FISH): FISH allows for the counting of chromosomes in a cell, primarily used to detect abnormalities in chromosome numbers like Down syndrome or translocations.

Who undergoes PGD?

The decision to undergo PGD is made in consultation with a specialist physician and genetic counselor, with the patient’s consent. PGD is also chosen by couples interested in gender selection for embryos.

At Dream IVF Cyprus, we guide women through the IVF process, determining the optimal period for egg retrieval. Through microinjection, eggs and sperm are fertilized in the lab, initiating embryo development. Biopsy is then performed on developing embryos, typically on day 3 or day 5. Genetic scans of the biopsied cells are conducted in the genetics laboratory, informing the selection of healthy embryos for transfer.

Dream IVF Cyprus’s PGD Service

Genetic conditions can impact future generations, underscoring the importance of proactive measures. With advancements in IVF technology, the prospects of parenthood have expanded for those facing fertility challenges. While genetic diversity enriches our lives, it can also pose risks to our children. PGD technology allows us to identify potential abnormalities before embryo transfer, empowering couples to make informed decisions and welcome healthy babies into the world.

Choosing a trusted provider for genetic diagnosis is paramount. At Dream IVF Cyprus, we offer comprehensive IVF and PGD services, leveraging cutting-edge technology. For further information about PGD, reach out to Dream IVF Cyprus, where patient health is always our priority.

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